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Salah Ebrahim

General Information

Updated: Acute Myeloid Leukemia (AML) Probe Panel by FISH

Effective 4/15/2026, in accordance with the 2024 American College of Medical Genetics and Genomic Technical Laboratory Standards, the Acute Myeloid Leukemia (AML) Probe Panel by FISH will now include:

• -5/5q Deletion
• -7/7q Deletion
• RUNX1::RUNX1T1 t(8;21) Fusion
• NUP98 (11p15.4) Rearrangement
• KMT2A (MLL) (11q23) Rearrangement
• CBFB::MYH11 inv(16) and t(16;16) Fusion
• TP53 (17p13.1) Deletion

The panel will no longer include BCR::ABL t(9;22) and PML::RARA t(15;17). These tests may still be ordered independently.

Additional Resource Link: ACMG Technical Standard Section E6.1-6.6 of the American College of Medical Genetics and Genomics (ACMG) Technical Laboratory Standards: Cytogenomic studies of acquired chromosomal abnormalities in neoplastic blood, bone marrow, and lymph nodes (https://www.gimjournal.org/article/S1098-3600(23)01070-5/fulltext)

Epic Code: LAB2111348

April 6, 2026 by
Advanced Technology Laboratory

New Test Available: Myxoid Liposarcoma Panel by FISH

We are pleased to announce the launch of the Myxoid Liposarcoma Panel by Fluorescence in situ Hybridization (FISH), now available for clinical ordering on Formalin-fixed, paraffin-embedded (FFPE) tissue.

The Myxoid Liposarcoma Panel by FISH includes:

  • CHOP (DDIT3) (12q13) Rearrangement
  • FUS (16p11) Rearrangement

These probes may also be ordered individually.

Test Ordering Information

Questions? We’re Here to Help

For additional clinical details or follow-up questions regarding this test, please use the contact us link above.

March 10, 2026 by
Advanced Technology Laboratory, Cytogenetics

Discontinuation of Low-Volume and Individual Fluorescence in situ Hybridization (FISH) Probes

Effective immediately, due to low test utilization and the high cost of maintaining proficiency, the following FISH tests will no longer be offered:

• Prader-Willi/Angelman (15q11-q13) by FISH

Recommended test is Angelman/Prader-Willi mPCR

• Smith Magenis (17p11) by FISH

• Williams (7q11,23) by FISH

If need arises for this test, please place an order for a Send out Genetics Miscellaneous and enter requested test in the comments. The testing will be sent out through Spectrum Health.

Any questions about referral testing may be directed to the Referral Department. Any questions or concerns regarding these changes may be directed to Dr. Salah Ebrahim in the Cytogenetics Laboratory. Continue Reading

April 27, 2022 by