The following information was updated in the Lab Catalog.
All changes are for Corewell Health Laboratories in Southwest and West Michigan. For Laboratories in Southeast Michigan, please visit: corewellhealth.org/labcatalog
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Test Update
Effective April 2, 2025, the Reflex HPV algorithm will more closely align with ASCCP recommendations. HPV testing will no longer be performed for a normal Pap result in patients aged 30 years and older when a provider orders HPV Reflex.
Specimens will qualify for HPV Reflex with a cytologic diagnosis of:
- ASCUS (Atypical Squamous Cells of Undetermined Significance) for patients aged 21 and older.
- LSIL (Low Grade Squamous Intraepithelial Lesion) for patients aged 25 and older.
HPV testing will continue to be performed for all Paps, regardless of results, for patients aged 30 years or older when a provider orders Co-Testing.
If a provider wishes to request HPV testing on a normal pap for patients under 30, they must either place an electronic order at the time of the initial pap order or request an add-on test for:
- HPV High Risk Screen with HPV Genotype Reflex – Cervical Source (LAB1231770)
- HPV High Risk Screen with HPV Genotype Reflex – Vaginal Source (LAB1230722)
Updated Pap and HPV Testing Algorithm
Effective March 21, 2025, Corewell Health Laboratories will update the preferred specimen type for β-hCG testing from plasma to serum (mint green top, lithium heparin gel to gold top, serum separator-SST gel). The move to serum is mostly driven by the laboratory’s need to reduce assay performance problems that can occur sporadically with the use of plasma. Although serum is the preferred specimen type plasma will remain an acceptable container.
If you have questions regarding the preanalytical handling process and the optimum tube offering, contact the lab for support.
TEST INFORMATION
On March 12th, 2025, the reporting for Protein Electrophoresis, 24 Hour Urine, do IFE if Indicated (LAB111444) and Protein Electrophoresis, Random Urine, do IFE if Indicated (LAB111445) will be updated to harmonize with Monoclonal Gammopathy Screen (LAB1230573) and Protein Electrophoresis, Serum, IFE if Indicated (LAB844).
The changes that will occur include the following.
- A single interpretive comment (Pathologist Interpretation Urine Protein Electrophoresis) that will encompass both the electrophoresis portion of the test and any immunotyping.
- Quantitation of monoclonal proteins will no longer be part of the interpretation but rather documented as discrete fields under Urine Protein Electrophoresis in result review. As a result, the interpretation will not include a comment about how the monoclonal protein has changed between studies.
- The quantitation of the monoclonal protein will only include mg/24-hour concentration and not the percentage.
TEST INFORMATION
- Protein Electrophoresis, 24 Hour Urine, do IFE if Indicated (LAB111444)
- Protein Electrophoresis, Random Urine, do IFE if Indicated (LAB111445)
Performing department: Immunochemistry (Corewell Health Reference Laboratory-West, Grand Rapids, MI)
A reagent bulletin from Roche has informed us that the recovery of the Anti-TPO assay has been falsely elevated for a reagent lot that was in use at Corewell Health Grand Rapids from September 2024 until March, 3, 2025. Based on the product evaluation, and in conjunction with a product and safety risk assessment, the remaining risk of false positive results with the Elecsys Anti-TPO assay is in the acceptable range.
We apologize for the inconvenience. Please reach out with any concerns or questions.
Best,
Dr. Alvarez
Yasel Alvarez, Ph.D.
Clinical Chemistry and Immunology
Corewell Health Reference Laboratory, West Michigan
Test Information
Thyroid Peroxidase Antibody, Blood Level [LAB516]
Clinical Implications
The risk of false positive results with the Elecsys anti-TPO assay is generally acceptable with respect to the given discrepancy.
Resources
Roche Customer Bulletin TP-02316
The following information was updated in the Lab Catalog.
All changes are for Corewell Health West Laboratories. For East and South locations, please visit: corewellhealth.org/labcatalog
The following information was updated in the Lab Catalog.
All changes are for Corewell Health West Laboratories. For East and South locations, please visit: corewellhealth.org/labcatalog
The following information was updated in the Lab Catalog.
All changes are for Corewell Health West Laboratories. For East and South locations, please visit: corewellhealth.org/labcatalog
Effective January 8, 2025, a new version of Beta CTX-1 (Cross Laps) will be implemented with the discontinuation of the previous version.
The analytical measuring range and reference ranges will be updated with the new version of the test. It is recommended to not directly compare the results between the new and old version of the test. If assistance is needed to aid in trending results between the new and old version of the test, please use the contact us link above or contact the Corewell Health Reference Laboratory West, Immunochemistry Department.
TEST INFORMATION
Discontinue: Beta CTX-1 (Cross Laps) LAB3656, Interface Code 55122
NEW: Beta CTX-1 (Cross Laps) LAB1231780, Interface Code 1231780
Effective immediately, platelet aggregation testing will require a pathology consult prior to scheduling for testing performed at Corewell Health Reference Laboratory West, Grand Rapids. This consult request must be completed prior to scheduling the patient for testing.
After consultation the testing may be ordered and scheduled.
As a reminder testing is performed for scheduled patients Monday – Thursday from 7:30 am-9:30 am at the 35 Michigan Street Laboratory. Patients should be resting, fasting, non-smoking, and should not be pregnant. Patients should avoid taking any prescription or over the counter medications known to affect platelet function for ten (10) days to two (2) weeks prior to the test. Click for a list of medications with known anti-platelet effects.
Test Information:
- Platelet Aggregation Studies -LAB2111147
- Pathology Consult-LAB1230850
- Please order a general pathology consult prior to scheduling all platelet aggregations. The consult must be completed prior to scheduling the test.
- Epic users view this tip sheet for more information: Orders – Pathology Consult.docx (sharepoint.com)
- Non-Epic or Non Corewell Health team members please order and fax a consult request form.
- Please order a general pathology consult prior to scheduling all platelet aggregations. The consult must be completed prior to scheduling the test.