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Test Update

General Information

MRSA PCR: Updated indications for ordering

Effective Date: September 3, 2025

The MRSA Screen PCR [LAB1231076] detects the presence or absence of colonization with methicillin-resistant Staphylococcus aureus (MRSA) and may be used to guide antimicrobial prophylaxis decisions. To improve and standardize test utilization across all Corewell Health regions, the following restrictions will be added to this test order:

  • Ordering will be restricted to one test every 7 days.
  • An indication for ordering must be provided for each order. Acceptable indications are:
    • Pneumonia
    • Skin and soft tissue (use for non-purulent infections)
    • Surgical prophylaxis

Studies have shown that there is minimal utility in re-testing within 2 weeks as MRSA conversion rates are low and the PCR negative predictive values remain high for at least 14 days after initial testing.

Absence of nasal colonization with MRSA cannot be used to reliably rule out MRSA infection in scenarios other than those listed above.

Test Information

MRSA Screen PCR [LAB1231076]

August 20, 2025 by
Hematology

Hematology Testing Updates (Corewell Health West Michigan)

Effective Wednesday, July 30, 2025, changes to result reporting will be implemented across all Hematology Departments at Corewell Health Laboratories. These updates will help align all regions within Corewell Health Hematology Departments to provide a high-quality and standardize patient care experience.

The following are the most impactful changes for the Corewell Health West Michigan Region: Continue Reading

July 18, 2025 by
General Information

Test Update: PD-L1

Effective July 30, 2025, PD-L1 testing will be performed at Corewell Health Reference Laboratory East and will no longer be a sendout to Neogenomics. Collection instructions and other information may have changed, please visit the lab catalog for more information.

For questions and inquiries, please use the “Contact Us” link above.

 

TEST INFORMATION

New test: PD-L1 [LAB3658]

Former test: PD-L1 to Neogenomics (LAB848)

July 18, 2025 by
Advanced Technology Laboratory, Cytology, General Information

Reflex HPV Testing Update

Effective April 2, 2025, the Reflex HPV algorithm will more closely align with ASCCP recommendations. HPV testing will no longer be performed for a normal Pap result in patients aged 30 years and older when a provider orders HPV Reflex.

Specimens will qualify for HPV Reflex with a cytologic diagnosis of:

  • ASCUS (Atypical Squamous Cells of Undetermined Significance) for patients aged 21 and older.
  • LSIL (Low Grade Squamous Intraepithelial Lesion) for patients aged 25 and older.

HPV testing will continue to be performed for all Paps, regardless of results, for patients aged 30 years or older when a provider orders Co-Testing.

If a provider wishes to request HPV testing on a normal pap for patients under 30, they must either place an electronic order at the time of the initial pap order or request an add-on test for:

  • HPV High Risk Screen with HPV Genotype Reflex – Cervical Source (LAB1231770)
  • HPV High Risk Screen with HPV Genotype Reflex – Vaginal Source (LAB1230722)

Updated Pap and HPV Testing Algorithm

Continue Reading

March 28, 2025 by
Chemistry, General Information

Collection Device Update: Chemistry β-hCG testing

Effective March 21, 2025, Corewell Health Laboratories will update the preferred specimen type for β-hCG testing from plasma to serum (mint green top, lithium heparin gel to gold top, serum separator-SST gel). The move to serum is mostly driven by the laboratory’s need to reduce assay performance problems that can occur sporadically with the use of plasma. Although serum is the preferred specimen type plasma will remain an acceptable container.
If you have questions regarding the preanalytical handling process and the optimum tube offering, contact the lab for support.
TEST INFORMATION
March 17, 2025 by
Immunochemistry, Test Spotlight

Update to Reporting for Urine Protein Electrophoresis Tests

On March 12th, 2025, the reporting for Protein Electrophoresis, 24 Hour Urine, do IFE if Indicated (LAB111444) and Protein Electrophoresis, Random Urine, do IFE if Indicated (LAB111445) will be updated to harmonize with Monoclonal Gammopathy Screen (LAB1230573) and Protein Electrophoresis, Serum, IFE if Indicated (LAB844).

The changes that will occur include the following.

  1. A single interpretive comment (Pathologist Interpretation Urine Protein Electrophoresis) that will encompass both the electrophoresis portion of the test and any immunotyping.
  2. Quantitation of monoclonal proteins will no longer be part of the interpretation but rather documented as discrete fields under Urine Protein Electrophoresis in result review. As a result, the interpretation will not include a comment about how the monoclonal protein has changed between studies.
  3. The quantitation of the monoclonal protein will only include mg/24-hour concentration and not the percentage.

TEST INFORMATION

  • Protein Electrophoresis, 24 Hour Urine, do IFE if Indicated (LAB111444)
  • Protein Electrophoresis, Random Urine, do IFE if Indicated (LAB111445)

Performing department: Immunochemistry (Corewell Health Reference Laboratory-West, Grand Rapids, MI)

March 9, 2025 by