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Endocrinology

General Information

Test Update: Vitamin D Testing Via Tandem Mass Spectrometry (LAB1230925)

Corewell Health Laboratories has discontinued routine Vitamin D testing via Tandem Mass Spectrometry (LAB1230925). The new test for diagnosing Vitamin D insufficiency and monitoring therapy is Vitamin D, 25-Hydroxy (LAB1231583), performed daily using an in-house immunoassay method.

Vitamin D screening for deficiency/insufficiency will now be conducted via immunoassay. Current requests for Vitamin D2/D3 by Mass Spectrometry will be sent out.

For any questions or concerns, please contact the Corewell Health West Laboratory.

 

TEST INFORMATION

Discontinue: LAB1230925 25-Hydroxyvitamin D2 and D3, Serum

Replacement: LAB1231583 Vitamin D 25 Hydroxy

June 27, 2025 by
Compliance & Safety

Anti-TPO Assay Falsely Elevated Recovery

A reagent bulletin from Roche has informed us that the recovery of the Anti-TPO assay has been falsely elevated for a reagent lot that was in use at Corewell Health Grand Rapids from September 2024 until March, 3, 2025. Based on the product evaluation, and in conjunction with a product and safety risk assessment, the remaining risk of false positive results with the Elecsys Anti-TPO assay is in the acceptable range.

We apologize for the inconvenience. Please reach out with any concerns or questions.

Best,

Dr. Alvarez
Yasel Alvarez, Ph.D.
Clinical Chemistry and Immunology
Corewell Health Reference Laboratory, West Michigan

Test Information

Thyroid Peroxidase Antibody, Blood Level [LAB516]

Clinical Implications

The risk of false positive results with the Elecsys anti-TPO assay is generally acceptable with respect to the given discrepancy.

Resources

Roche Customer Bulletin TP-02316

March 7, 2025 by
Toxicology

Update to Vitamin D Testing

Effective February 28th, 2023, Vitamin D 25-Hydroxy Level (25-OH Vitamin D) [LAB535] will be replaced by 25-Hydroxyvitamin Level D2 and D3 [LAB1230925]. Send out testing for 25-Hydroxyvitamin D2 and D3, Serum [LAB1230428] to Mayo will be discontinued. The testing methodology will change from an immunoassay to liquid chromatography-mass spectrometry.

The new test will include concentrations for

  • 25-hydroxyvitamin D2
  • 25-hydroxyvitamin D3
  • 25-hydroxyvitamin D Total

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February 22, 2023 by
Chemistry

Updates: Chemistry Reference Ranges

Effective August 2, 2022, reference ranges for the below tests will be updated to better align with the vendor’s recommendation and with Spectrum Health Lakeland Laboratory. Please click on the links below and scroll to the Reference Range field to see the updated ranges.

• Lithium Level [LAB29]

• PTH Intact [LAB108]

• IgM Level [LAB72]

• IgA Level [LAB73]

• CA 125 Level [LAB155]

• C4 Complement Level [LAB151]

• C3 Complement Level [LAB152]

• Albumin Level [LAB45]

• Transferrin Level [LAB133]

Questions or inquiries may be directed to the “Contact Us” link above.

August 2, 2022 by
Chemistry, General Information

Test Update: Thyroglobulin Antibody

Effective immediately, Thyroglobulin Antibody will be performed at Spectrum Health Reference Laboratory (SHRL, Grand Rapids, MI) and will no longer be a sendout to Mayo Clinical Laboratories. Collection instructions and other information may have changed, please visit the lab catalog for more information.

Thyroglobulin Tumor Marker will continue to be a sendout. If a Thyroglobulin Antibody is ordered with a Thyroglobulin Tumor Marker, then the Thyroglobulin Antibody will automatically be canceled as Mayo Clinic Laboratories will perform the Thyroglobulin Antibody as well as the Tumor Marker.

For questions and inquiries, please use the “Contact Us” link above.

 

TEST INFORMATION

New test: Thyroglobulin Antibody [LAB1230840] 

Former test: Thyroglobulin Antibody, Serum [LAB1230457]

Mentioned Test: Thyroglobulin, Tumor Marker, Serum [LAB864]

November 18, 2021 by