Effective 10/01/2025, Apixaban level testing will be available at Corewell Health Reference Laboratory West.
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Hemostasis/Coagulation
Effective immediately, platelet aggregation testing will require a pathology consult prior to scheduling for testing performed at Corewell Health Reference Laboratory West, Grand Rapids. This consult request must be completed prior to scheduling the patient for testing.
After consultation the testing may be ordered and scheduled.
As a reminder testing is performed for scheduled patients Monday – Thursday from 7:30 am-9:30 am at the 35 Michigan Street Laboratory. Patients should be resting, fasting, non-smoking, and should not be pregnant. Patients should avoid taking any prescription or over the counter medications known to affect platelet function for ten (10) days to two (2) weeks prior to the test. Click for a list of medications with known anti-platelet effects.
Test Information:
- Platelet Aggregation Studies -LAB2111147
- Pathology Consult-LAB1230850
- Please order a general pathology consult prior to scheduling all platelet aggregations. The consult must be completed prior to scheduling the test.
- Epic users view this tip sheet for more information: Orders – Pathology Consult.docx (sharepoint.com)
- Non-Epic or Non Corewell Health team members please order and fax a consult request form.
- Please order a general pathology consult prior to scheduling all platelet aggregations. The consult must be completed prior to scheduling the test.
Effective December 2, 2024 at 08:00 AM, Corewell Health West Laboratory Coagulation Department will be updating the reference range for several assays. The following will be impacted by these changes:
APTT testing for the BCS XP analyzers will be updating to 22.0 – 27.0 seconds.
This will include the following tests:
- aPTT Direct Thrombin Inhibitor (LAB1230880) (APTT-DTI)
- Mixing Studies, aPTT (LAB326)
- APTT (LAB325)
- APTT Heparin Neutralization (LAB3377)
Effective December 2, 2024 at 08:00 AM, the Corewell Health West and South Coagulation Departments will be updating the reference range of the Fibrinogen Level (LAB 314) to 190-450 mg/ dL.
Questions may be directed to the Coagulation Laboratory using the Contact Us link above.
Effective January 17, 2024, UFH Anti-IIa testing will be performed at both Corewell Health Reference Laboratory West and Blodgett Immediate Response Laboratory in Grand Rapids.
Effective August 23, 2023, Corewell Health Coagulation Laboratory will go live with UFH Anti-IIa testing.
The Anti-IIa 2 stage heparin assay is a chromogenic assay for measuring the activity of unfractionated heparin. This method only tests unfractionated heparin.
This heparin assay is a two stage Anti IIa ( 2 Stages Heparin Assay) based on the inhibition of a constant amount of Thrombin (IIa) by the tested heparin in the presence of exogenous antithrombin.
Corewell Health Laboratory (Grand Rapids) Coagulation laboratory is pleased to announce a change to our von Willebrand factor (VWF) activity test. The historical test von Willebrand ristocetin cofactor (LAB335) will be retired and replaced by von Willebrand factor activity (VWF activity, LAB1230904) on January 17, 2023.
Effective December 6, 2021, Spectrum Health Reference Laboratory (SHRL) Coagulation department will go live with a new lot of Prothrombin Time (Protime/PT) reagents. The reference range for the PT will be adjusted to reflect this reagent lot change and align with our Regional Laboratories. The new reference range will be 9.5 – 12.0 seconds. There will be no change to the INR ranges.
| Test | Current Reference Range | New Reference Range |
| Prothrombin Time (PT) | 9.7 – 12.6 seconds | 9.5 – 12.0 seconds |