Effective 4/15/2026, in accordance with the 2024 American College of Medical Genetics and Genomic Technical Laboratory Standards, the Acute Myeloid Leukemia (AML) Probe Panel by FISH will now include:
• -5/5q Deletion
• -7/7q Deletion
• RUNX1::RUNX1T1 t(8;21) Fusion
• NUP98 (11p15.4) Rearrangement
• KMT2A (MLL) (11q23) Rearrangement
• CBFB::MYH11 inv(16) and t(16;16) Fusion
• TP53 (17p13.1) Deletion
The panel will no longer include BCR::ABL t(9;22) and PML::RARA t(15;17). These tests may still be ordered independently.
Additional Resource Link: ACMG Technical Standard Section E6.1-6.6 of the American College of Medical Genetics and Genomics (ACMG) Technical Laboratory Standards: Cytogenomic studies of acquired chromosomal abnormalities in neoplastic blood, bone marrow, and lymph nodes (https://www.gimjournal.org/article/S1098-3600(23)01070-5/fulltext)
Epic Code: LAB2111348
No Comments